Polynucleotide Therapy

Injected DNA fragments that support skin repair, used particularly for thin under eye skin.

Black and white photograph of a gloved hand holding a fine needle above the upper lip, the other gloved hand steadying the chin.
Injectables

What it treats

  • Thin, dark or crepey under eye skin
  • Skin repair after inflammation or acne
  • Overall skin resilience
  • Neck texture
  • Scalp health alongside hair treatments

How it works

Purified polynucleotide chains are injected into the skin, where they act as a scaffold and prompt fibroblasts to behave more like younger cells. The effect is regenerative rather than volumising: the skin becomes thicker and better hydrated over a course. It is used a lot around the eyes because the skin there is too thin for most other injectables.

Typical course

Three sessions spaced two to three weeks apart, then every six months.

Who it is not suitable for

Not used if you are pregnant or breastfeeding, if you have an autoimmune condition affecting the skin, or if you have a fish allergy, since the source material is derived from fish DNA. Tell us about allergies before booking.

Every treatment here is assessed at consultation first. This list covers the common reasons we would not proceed, and it is not exhaustive. Bring your medication list and tell us about anything you are being treated for.

Questions people ask

Will it get rid of my dark circles?

It depends what is causing them. Where the darkness is thin skin showing the vessels underneath, thickening the skin genuinely helps. Where it is a hollow or pigmentation, this will not be the answer and we will say so at consultation.

Is there good evidence for it?

There is a reasonable and growing body of clinical work, particularly on wound healing and skin quality. It is newer than hyaluronic acid, and we will describe it as promising rather than proven beyond doubt.

Can it be combined with other injectables?

Yes, and it often is. A common plan is polynucleotides to improve the skin quality first, then filler for structure once the skin is in better condition.

Related treatments

Skin Boosters

Micro injections of hydrating hyaluronic acid spread across an area to improve skin quality.

From £250

Profhilo

An injectable hyaluronic acid that spreads under the skin to hydrate and firm rather than fill.

From £350

PRP Hair Restoration

Your own concentrated platelets injected into the scalp to support thinning follicles.

From £350

Looking for something else?

Or just ask

If it is not on the menu, or you are not sure what to call it, say so in your own words and the team will answer. Ask about this treatment.